Friday, February 08, 2013

Nature: Small-molecule drug drives cancer cells to suicide

Studies in mice show therapy is effective even in hard-to-treat brain tumours:
Cancer researchers have pinned down a molecule that can kick-start the body’s own tumour-destroying systems, triggering cell death in cancerous but not healthy tissue in mice.

The molecule, TIC10, activates the gene for a protein called TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand), which has long been a target for cancer researchers looking for drugs that would avoid the debilitating effects of conventional therapies...


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